Real or fake? Mysterious ghost pictures investigated

child

Cemetery ghost baby: Visiting the grave of her daughter in a cemetery in Queensland in 1947 a woman named Mrs Andrews took this picture of what she thought was a bare grave. She was shocked to see, when she got the film developed that there seemed to be the figure of a child sitting on the grave. Mrs Andrews didn’t recognise the child and her own daughter died at the age of 17, much older than the apparent age of this infant. A paranormal investigator in the late 1990s, Tony Healy, visited the site and discovered the graves of two baby girls. –Burden’s judgment: FAKE. Picture: Supplied

FRIDAY the 13th means black cats, bad luck, superstitions and … ghosts.

On this auspicious day we thought we’d bring you some of the best-known ghost images of all time.

car

Back Seat Ghost: Mr and Mrs Chinnery were visiting the grave of Mabel Chimmery’s mother one day in 1959. Mabel, before walking back to the car, took an impromptu photo of her husband who was sitting alone in the car. Or so he thought. Upon getting the film developed Mabel realised there was another figure in the car, sitting in the back seat, which happened to look a lot like her late mother! — Burden’s judgment: TOO CLOSE TO CALL. Picture: Supplied

These are some of the most famous ghost pictures of all time. In a time before Photoshop and digital manipulation these are the pictures that had experts stumped.

Are they real or are they fake? Is that really a ghostly spectre appearing beyond the grave or is it just a smudge on the film?

 

Raynham Hall

This portrait of “The Brown Lady” ghost is arguably the most famous and well-regarded ghost photograph ever taken. The ghost is thought to be that of Lady Dorothy Townshend, wife of Charles Townshend, 2nd Viscount of Raynham, residents of Raynham Hall in Norfolk, England in the early 1700s. This famous photo was taken in September, 1936 by Captain Provand and Indre Shira, two photographers who were assigned to photograph Raynham Hall for Country Life magazine. The figure has been seen many times on the staircase, carrying a lantern, grinning and appearing to have her eyes gouged out. –Burden’s judgment: PROBABLY FAKE. Picture: Supplied

We asked Rick Burden, founder of the Ghost Hunters of Australia website and the Down Under Spirit Team, about whether he thought they were the real deal.

Based on the Gold Coast, Burden’s team of 12 undertake psychic investigations where they can do anything from house “cleanings” (not the kind that involves the mop and bucket), spirit removals, possession removals or a combination of all three. They offer advice and help with anything paranormal-related for those that come in contact with something they can’t quite explain.

 

faint outline

This photograph of the Combermere Abbey library was taken in 1891 by Sybell Corbet. The faint outline of a man can be seen sitting in the chair on the left. It is believed that this is Lord Combermere himself. Interestingly though at the time Sybell Corbet took the above photo, Combermere’s funeral was taking place some four miles away. –Burden’s judgment: FAKE. Picture: Supplied

Just like in the Hollywood classic Ghostbusters Burden and his team will help rid you of your ghost problem as quickly as they can or if not they’ll tell you where your local ghost hunter is. They’ll even take a look at that weird blur in the background of that picture you took that time to see if it’s a ghost. Fielding at least one call or request for help a week Burden’s team will either offer their own help or put you in touch with a similar team closer to you.

 

image

The Watcher: This image, taken in 1959 in Alice Springs, seems to capture what looks like a female figure looking out from behind the scrub wearing a long white gown. Is she holding binoculars? Or is it just a trick of light? Perhaps a double exposure accidentally printed onto one image? –Burden’s judgment: TOO CLOSE TO CALL. Picture: Supplied

The most common problem Burden and his team come across in the field is when people accidentally bring back “entities” when they incorrectly use an ouija board or stage a seance.

How exactly does Burden ‘catch’ a ghost?

 

tall shrouded figure

This photograph was taken in 1963 by Reverend K.F. Lord at Newby Church in North Yorkshire, England. He claims that the room was empty of people when he took the photo. Alarmingly it looks like a tall shrouded figure standing in front of the alter. Supposedly the photo has been scrutinised by photo experts who say the image is not the result of a double exposure. –Burden’s judgment: PROBABLY FAKE Picture: Supplied

Using equipment such as full spectrum cameras, shadow detectors, vibration detectors, sound recorders, laser grid pens and electro magnetic field detectors allow the team to detect and confront an apparition.

When it comes down to it Burden is surprised there aren’t more ghosts captured on camera: “My opinion on this, is that we may not quite yet have the true correct technology to capture the paranormal on a regular basis.

“I believe we have the partial technology, which is why the paranormal can be intermittently captured, but not the full, true technology to do it on a regular basis.”

 

picture

This picture, taken in 2008, was taken by photographer Neil Sandbach, at a farm in England while scouting locations for a couple about to get married. He was shocked to discover what looks like a figure standing in a spot that he was quite sure was empty when he took the picture. The owners of the farm have admitted they’d seen the figure of a child dressed in nightclothes on several occasions around the barn. –Burden’s judgment: POSSIBLE FAKE Picture:

When analysing ghost pictures, however, Burden admits: “It can also be almost impossible to prove to people that a captured image is real.”

But there are ways to cut down the obvious fakes from the rest using digital technology.

“Unfortunately, there are a lot of ways that an image can be altered or tampered with these days, and we tend to get a lot of people that think they are funny by sending us obviously faked images and wasting our time.

“We just focus on helping those that are legitimate, and legitimately need help.”

Need help with a ghostly problem? Check out Burden’s extensive listing of Ghost Hunters in your area.

 

respected furniture dealer

This image taken in the early 1900s of a beautiful antique cabinet was taken by a respected furniture dealer at the time. The photographer was at a loss to explain the transparent hand that appears to rest on top of the bureau. Perhaps a former owner reluctant to let it go? –Burden’s judgment: FAKE. Picture: Supplied

Starpharma to develop improved cancer drug

Source: News

BIOTECH Starpharma Holdings says it has improved a blockbuster drug that is mainly used to treat colon and colorectal cancer.

Starpharma has conducted a pre-clinical study of the effects of a dendrimer-enhanced nanoparticle version of the drug oxaliplatin on colon cancer.

The results showed that the enhanced drug was better at inhibiting tumours and reducing toxic side-effects than the non-enhanced drug.

Oxaliplatin is sold as Eloxatin by Sanofi and in 2012 generated sales of about $US2 billion (currently around $A2.16 billion).

“These positive results achieved with Starpharma’s dendrimer-enhanced oxaliplatin nanoparticles are the subject of a new patent filing and given the obvious commercial potential, Starpharma now intends to advance dendrimer-enhanced oxaliplatin formulations into development,” the company said in a statement on Wednesday.

Dendrimers are a type of synthetic nanoscale polymer that is highly regular in size and structure and suited to pharmaceutical uses.

Shares in Starpharma were 1.5 cents lower at 98.5 cents at 1253 AEST.

Transcript: Obama’s address on Syria

Source: CNN

President Barack Obama speaks about Syria in a televised address on Sept. 10, 2013.

President Barack Obama speaks about Syria in a televised address on Sept. 10, 2013

http://www.cnn.com/video/data/2.0/video/politics/2013/09/11/sot-obama-nation-address-u-s-strike-on-syria.cnn.html

Targeted military strikes against Syria would deter Syria’s government from using chemical weapons and make clear to the world that the use of such weapons won’t be tolerated, President Barack Obama said Tuesday night in a televised address to the American public.

He also pointed to “encouraging signs” in diplomatic efforts to address the crisis, crediting these “in part because of the credible threat of U.S. military action.” But if diplomacy fails, the U.S. and its military will “be in position to respond,” Obama said, not ruling out military intervention in the war-torn country.

Read a transcript of his remarks below.

My fellow Americans, tonight I want to talk to you about Syria, why it matters and where we go from here. Over the past two years, what began as a series of peaceful protests against the oppressive regime of Bashar al-Assad has turned into a brutal civil war.

Over 100,000 people have been killed. Millions have fled the country. In that time, America’s worked with allies to provide humanitarian support, to help the moderate opposition, and to shape a political settlement, but I have resisted calls for military action because we cannot resolve someone else’s civil war through force, particularly after a decade of war in Iraq and Afghanistan.

The situation profoundly changed, though, on August 21st, when Assad’s government gassed to death over 1,000 people, including hundreds of children. The images from this massacre are sickening: men, women, children lying in rows, killed by poison gas, others foaming at the mouth, gasping for breath, a father clutching his dead children, imploring them to get up and walk.

On that terrible night, the world saw in gruesome detail the terrible nature of chemical weapons and why the overwhelming majority of humanity has declared them off-limits, a crime against humanity and a violation of the laws of war.

This was not always the case. In World War I, American G.I.s were among the many thousands killed by deadly gas in the trenches of Europe. In World War II, the Nazis used gas to inflict the horror of the Holocaust. Because these weapons can kill on a mass scale, with no distinction between soldier and infant, the civilized world has spent a century working to ban them. And in 1997, the United States Senate overwhelmingly approved an international agreement prohibiting the use of chemical weapons, now joined by 189 governments that represent 98 percent of humanity.

On August 21st, these basic rules were violated, along with our sense of common humanity. No one disputes that chemical weapons were used in Syria. The world saw thousands of videos, cell phone pictures, and social media accounts from the attack, and humanitarian organizations told stories of hospitals packed with people who had symptoms of poison gas.

Moreover, we know the Assad regime was responsible. In the days leading up to August 21st, we know that Assad’s chemical weapons personnel prepared for an attack near an area where they mix sarin
gas. They distributed gas masks to their troops. Then they fired rockets from a regime-controlled area into 11 neighborhoods that the regime has been trying to wipe clear of opposition forces. Shortly after those rockets landed, the gas spread, and hospitals filled with the dying and the wounded.

We know senior figures in Assad’s military machine reviewed the results of the attack and the regime increased their shelling of the same neighborhoods in the days that followed. We’ve also studied samples of blood and hair from people at the site that tested positive for sarin.

When dictators commit atrocities, they depend upon the world to look the other way until those horrifying pictures fade from memory, but these things happened. The facts cannot be denied.

The question now is what the United States of America and the international community is prepared to do about it, because what happened to those people — to those children — is not only a violation of international law, it’s also a danger to our security. Let me explain why.

If we fail to act, the Assad regime will see no reason to stop using chemical weapons. As the ban against these weapons erodes, other tyrants will have no reason to think twice about acquiring poison gas and using them. Over time, our troops would again face the prospect of chemical warfare on the battlefield, and it could be easier for terrorist organizations to obtain these weapons and to use them to attack civilians.

If fighting spills beyond Syria’s borders, these weapons could threaten allies like Turkey, Jordan and Israel. And a failure to stand against the use of chemical weapons would weaken prohibitions against other weapons of mass destruction and embolden Assad’s ally, Iran, which must decide whether to ignore international law by building a nuclear weapon or to take a more peaceful path.

This is not a world we should accept. This is what’s at stake. And that is why, after careful deliberation, I determined that it is in the national security interests of the United States to respond to the Assad regime’s use of chemical weapons through a targeted military strike. The purpose of this strike would be to deter Assad from using chemical weapons, to degrade his regime’s ability to use them, and to make clear to the world that we will not tolerate their use.

That’s my judgment as commander-in-chief, but I’m also the president of the world’s oldest constitutional democracy. So even though I possess the authority to order military strikes, I believed it was right in the absence of a direct or imminent threat to our security to take this debate to Congress. I believe our democracy is stronger when the president acts with the support of Congress, and I believe that America acts more effectively abroad when we stand together. This is especially true after a decade that put more and more war-making power in the hands of the president and more and more burdens on the shoulders of our troops, while sidelining the people’s representatives from the critical decisions about when we use force.

Now, I know that after the terrible toll of Iraq and Afghanistan, the idea of any military action — no matter how limited — is not going to be popular. After all, I’ve spent four-and-a-half years working to end wars, not to start them.

Our troops are out of Iraq. Our troops are coming home from Afghanistan. And I know Americans want all of us in Washington –especially me — to concentrate on the task of building our nation here at home, putting people back to work, educating our kids, growing our middle class. It’s no wonder then that you’re asking hard questions.

So let me answer some of the most important questions that I’ve heard from members of Congress and that I’ve read in letters that you’ve sent to me. First, many of you have asked, won’t this put us on a slippery slope to another war? One man wrote to me that we are still recovering from our involvement in Iraq. A veteran put it more bluntly: This nation is sick and tired of war.

My answer is simple. I will not put American boots on the ground in Syria. I will not pursue an open-ended action like Iraq or Afghanistan. I will not pursue a prolonged air campaign like Libya or Kosovo. This would be a targeted strike to achieve a clear objective, deterring the use of chemical weapons and degrading Assad’s capabilities.

Others have asked whether it’s worth acting if we don’t take out Assad. Now, some members of Congress have said there’s no point in simply doing a pinprick strike in Syria.

Let me make something clear: The United States military doesn’t do pinpricks. Even a limited strike will send a message to Assad that no other nation can deliver.

I don’t think we should remove another dictator with force. We learned from Iraq that doing so makes us responsible for all that comes next. But a targeted strike can makes Assad — or any other dictator — think twice before using chemical weapons.

Other questions involve the dangers of retaliation. We don’t dismiss any threats, but the Assad regime does not have the ability to seriously threaten our military. Any other — any other retaliation they might seek is in line with threats that we face every day. Neither Assad nor his allies have any interest in escalation that would lead to his demise, and our ally, Israel, can defend itself with overwhelming force, as well as the unshakable support of the United States of America.

Many of you have asked a broader question: Why should we get involved at all in a place that’s so complicated and where, as one person wrote to me, those who come after Assad may be enemies of human rights?
It’s true that some of Assad’s opponents are extremists. But al Qaida will only draw strength in a more chaotic Syria if people there see the world doing nothing to prevent innocent civilians from being gassed to death.

The majority of the Syrian people, and the Syrian opposition we work with, just want to live in peace, with dignity and freedom. And the day after any military action, we would redouble our efforts to achieve a political solution that strengthens those who reject the forces of tyranny and extremism.

Finally, many of you have asked, why not leave this to other countries or seek solutions short of force? As several people wrote to me, we should not be the world’s policemen.

I agree. And I have a deeply held preference for peaceful solutions. Over the last two years, my administration has tried diplomacy and sanctions, warnings and negotiations, but chemical weapons were still used by the Assad regime.

However, over the last few days, we’ve seen some encouraging signs, in part because of the credible threat of U.S. military action, as well as constructive talks that I had with President Putin. The Russian government has indicated a willingness to join with the international community in pushing Assad to give up his chemical weapons. The Assad regime has now admitting that it has these weapons and even said they’d join the Chemical Weapons Convention, which prohibits their use.

It’s too early to tell whether this offer will succeed, and any agreement must verify that the Assad regime keeps its commitments, but this initiative has the potential to remove the threat of chemical weapons without the use of force, particularly because Russia is one of Assad’s strongest allies.

I have therefore asked the leaders of Congress to postpone a vote to authorize the use of force while we pursue this diplomatic path. I’m sending Secretary of State John Kerry to meet his Russian counterpart on Thursday, and I will continue my own discussions with President Putin.

I’ve spoken to the leaders of two of our closest allies – France and the United Kingdom — and we will work together in consultation with Russia and China to put forward a resolution at the U.N. Security Council requiring Assad to give up his chemical weapons and to ultimately destroy them under international control.

We’ll also give U.N. inspectors the opportunity to report their findings about what happened on August 21st, and we will continue to rally support from allies from Europe to the Americas, from Asia to the Middle East, who agree on the need for action.

Meanwhile, I’ve ordered our military to maintain their current posture to keep the pressure on Assad and to be in a position to respond if diplomacy fails. And tonight I give thanks, again, to our military and their families for their incredible strength and sacrifices.

My fellow Americans, for nearly seven decades, the United States has been the anchor of global security. This has meant doing more than forging international agreements; it has meant enforcing them. The burdens of leadership are often heavy, but the world’s a better place because we have borne them.

And so to my friends on the right, I ask you to reconcile your commitment to America’s military might with the failure to act when a cause is so plainly just.

To my friends on the left, I ask you to reconcile your belief in freedom and dignity for all people with those images of children writhing in pain and going still on a cold hospital floor, for sometimes resolutions and statements of condemnation are simply not enough.

Indeed, I’d ask every member of Congress and those of you watching at home tonight to view those videos of the attack, and then ask, what kind of world will we live in if the United States of
America sees a dictator brazenly violate international law with poison gas and we choose to look the other way?

Franklin Roosevelt once said, “Our national determination to keep free of foreign wars and foreign entanglements cannot prevent us from feeling deep concern when ideas and principles that we have cherished are challenged.”

Our ideals and principles, as well as our national security, are at stake in Syria, along with our leadership of a world where we seek to ensure that the worst weapons will never be used.

America is not the world’s policeman. Terrible things happen across the globe, and it is beyond our means to right every wrong, but when with modest effort and risk we can stop children from being gassed to death and thereby make our own children safer over the long run, I believe we should act.

That’s what makes America different. That’s what makes us exceptional. With humility, but with resolve, let us never lose sight of that essential truth.

Thank you, God bless you, and God bless the United States of America.

Golden ornaments from holy Torah and 36 gold coins among treasure found in Temple Mount cache

Source: News

The gold Torah medallion uncovered from a ruined Byzandium-era building on the south side of Jerusalem's Temple Mount.

The gold Torah medallion uncovered from a ruined Byzandium-era building on the south side of Jerusalem’s Temple Mount.

A GOLDEN treasure of religious artefacts and coins has been found at the base of Jerusalem’s Temple Mount.

Archaeologists have recovered two bundles buried in a ruined Byzantine public structure a mere 50 meters from the Temple Mount’s southern wall, not far from the disputed Al Aqsa mosque.

Inside was 36 gold coins, gold and silver jewellery and a distinctive gold religious medallion.

The 10cm medallion is etched with the Temple’s logo a menorah candelabrum as well as other religious iconography such as a shofar (ram’s horn) and a Torah scroll. Attached to a gold chain, its discoverers believe the medallion was an ornament attached to a Torah.

It was found buried in a small hole under the floor, along with a smaller golden medallion and several gold and silver clasps and pendants which are believed to have been attached to the same document.

The second bundle appeared to have been abandoned as its owners fled or to have been hidden higher in the structure with its contents strewn over the floor.

 

The gold coins date from the fourth century through to the seventh century AD.

The gold coins date from the fourth century through to the seventh century AD.

The 36 Byzantine gold coins have a date range from the middle of the fourth century AD through to the early seventh century. Other items of treasure included large gold earrings, a gold-plated hexagonal prism and a silver ingot.

The discovery was made by Hebrew University of Jerusalem archaeologist Dr Eilat Mazar who is responsible for the controversial excavations at the Ophel site adjoining Muslim sectors of the Temple Mount along its southern wall.

Dr Mazar said he believes the gold was abandoned during a Persian conquest of Jerusalem in 614AD.

She has called the find “a breathtaking, once-in-a-lifetime discovery.”

“We have been making significant finds from the First Temple Period in this area, a much earlier time in Jerusalem’s history, so discovering a golden seven-branched Menorah from the seventh century AD at the foot of the Temple Mount was a complete surprise.”

The expedition, funded by investors from New York, made headlines earlier this year when it claimed to have found an ancient Canaanite inscription, possibly the oldest piece of writing so far found in the city.

Torah

Hebrew University of Jerusalem archaeologist Dr. Eilat Mazar displays the 10-cm gold medallion discovered at the foot of the Temple Mount in Jerusalem. Picture: Ouria Tadmor

Largest Ferris wheel nears completion in Las Vegas

Source: News

The High Roller. Picture: Las Vegas Convention and Visitors Authority

The High Roller. Picture: Las Vegas Convention and Visitors Authority

The outer wheel of the 55-storey High Roller ride is scheduled to be hoisted into place today. Picture: AP

The outer wheel of the 55-storey High Roller ride is scheduled to be hoisted into place today. Picture: AP

THE madcap carnival on the Las Vegas Strip is getting another over-the-top addition: the world’s largest Ferris wheel.

The outer wheel of the 55-storey High Roller ride is scheduled to be hoisted into place today. The gargantuan project is now visible from all over the city, including the airport. Early next year, it will be outfitted with 1500 LED lights, and start its slow spin.

“It’s going to be an icon,” Project Director David Codiga said. “It’s going to be a part of your visit to Las Vegas if you ride it or not. It’s more or less impossible not to see it if you come here.”

Caesars Entertainment Corp., which owns more casinos than any other US gambling company, is building the ride as part of its $550 million Linq development, a new outdoor plaza across the street from Caesars Palace.

The walking mall, sandwiched between the Flamingo and Harrah’s hotel-casino, is expected to open this winter. It’s designed to lure gen Xers and millennials, demographics Caesars believes will contribute a majority of Sin City tourist dollars by 2015.

City after city has jumped to put a new spin on the classic carnival attraction over the past decade.

The High Roller will be 30 metres taller than the London Eye, which opened in 2000, nine metres taller than China’s Star of Nanchang, which opened in 2006, and 2.7m taller than the Singapore Flyer, which opened in 2008.

These giant urban Ferris wheels typically transport riders in large, fixed capsules instead of the smaller, teetering baskets most people remember from childhood.

High Roller riders will have to take a break from gambling and smoking when they enter one of the 28 glass capsules attached to the gargantuan wheel, Codiga said, but they will be able to take in the marquee-lit panoramic views with a drink in hand.

The wheel, which has been under construction since 2011, is taller than the Bellagio hotel-casino but still dwarfed by the Stratosphere observation tower, which rises more than 305m. It will carry 1.6 million kilograms of steel – the equivalent of about 200 Hummers- and will take 30 minutes to make one revolution.

A design image of the ride. Picture Las Vegas Convention and Visitors Authority

A design image of the ride. Picture Las Vegas Convention and Visitors Authority

And, because this is Las Vegas where overstimulation is the sales pitch, it will feature audiovisual shows in each 40-person pod designed to complement the views.

Codiga, who previously worked for the theme park company Universal Studios, said he doesn’t want visitors to get bored as the ride ascends and descends.

Tickets will be comparable to the London ride, which costs about $30, according to Caesars spokeswoman Christina Karas. She declined to say to how much it cost to build the ride.

The High Roller is not the only big wheel jostling for a place among the volcanoes and dancing fountains of the tourist corridor.

A rival company is building SkyVue, a 500-foot observation wheel across from Mandalay Bay at the southern end of the Strip that will feature video screens broadcasting ads. That project is expected to open in mid-2015, according to developer David Gaffin.

Last spring, a group of developers revealed plans for a third wheel – the London Thrill – near the CityCenter complex in the middle of the Strip.

The High Roller will also likely have to surrender its tallest in the world title before long. Another monster wheel is looming in New York City, where Mayor Michael Bloomberg announced plans last year for a ride on Staten Island’s waterfront.

Other wheels may grow taller, Codiga said, “but the High Roller will allow you to float over Las Vegas.”

There’s a revolution occurring in cancer treatment, and it could mean the end of chemotherapy

When it comes to taming tumors, the strategy has always been fairly straightforward. Remove the offending and abnormal growth by any means, in the most effective way possible. And the standard treatments used today reflect this single-minded approach — surgery physically cuts out malignant lesions; chemotherapy agents dissolve them from within; and radiation seeks and destroys abnormally dividing cells.

There is no denying that such methods work; deaths from cancer have dropped by around 20% in the U.S. over the past two decades. But as effective as they are, these interventions can be just as brutal on the patient as they are on a tumor. So researchers were especially excited by a pair of studies published in the New England Journal of Medicine last week that showed a new type of anti-cancer drug, which works in an entirely different way from chemotherapy, helped leukemia patients tally up to an 83% survival rate after being treated for two years.

(MORE: On the Horizon at Last, Cancer Drugs that Harness the Body’s Own Immune System)

The report was only the latest to emerge since 2001, when imatinib, or Gleevec, the first drug to veer away from the take-all-comers approach on which cancer therapies have been built, accomplished similar improvements in survival for patients with chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST).

Could the end of chemotherapy be near?

“It’s a question we are all asking,” says Dr. Martin Tallman, chief of the leukemia service at Memorial Sloan Kettering Cancer Center. “I think we are definitely moving farther and farther away from chemotherapy, and more toward molecularly targeted therapy.”

It’s the difference between carpet bombing and “smart bomb” strategies for leveling an enemy – in this case a fast-growing mass of cells that can strangle and starve surrounding normal tissues. Targeted therapies, as they are called, are aimed at specific pathways that tumor cells use to thrive, blocking them in the same way that monkeying with a car’s ignition, or it’s fuel intake, can keep it from running properly. The advantage of such precise strategies is that they leave healthy cells alone, which for patients means fewer side effects and complications.

(MORE: Self-Sabotage: Why Cancer Vaccines Don’t Work)

“The field is moving toward using the right drugs at the right time in the right patients,” says Dr. George Demetri, senior vice president of experimental therapeutics at the Dana Farber Cancer Institute. “We’re moving toward a more precise understanding of cancer, and being able to tailor therapies toward an individual’s cancer.”

In the case of the NEJM studies, researchers were able to target an active receptor on immune cells responsible for enticing them to grow out of control, blocking the protein and essentially shutting down two different type of leukemia tumors.

(MORE: Young Survivors)

Already, patients diagnosed with GIST can avoid chemotherapy altogether, thanks to Gleevec. “No patient diagnosed with GIST should be getting chemotherapy today,” says Demetri. Patients who develop certain types of lung cancer or melanoma caused by a cancer-promoting mutation known as BRAF are also starting to replace toxic chemotherapy agents with new, more precise medications designed to thwart the BRAF pathway. And a study presented at the most recent meeting of the American Society of Clinical Oncology showed for the first time that a chemotherapy-free regimen led to a higher survival rate after two years than traditional chemotherapy for acute promyelocytic leukemia, a cancer of the bone marrow.

The refined approach does have a weakness, however. Cancer cells, like bacteria and viruses, are wily enough to bypass roadblocks to their survival, and often mutate to overcome the effects of targeted drugs. That’s the case for a small percentage of patients on Gleevec. But even that shortcoming isn’t insurmountable. With growing knowledge about the molecular processes that drive tumor biology, researchers are able to design medications that thwart cancer cells’ attempts to bypass medications. It’s all about staying one or two steps ahead of the cancer, and already, researchers are testing drugs that address Gleevec resistance and hoping to widen the resistance gap. “The field is moving so fast that there are new drugs already being developed to tackle new resistant clones,” says Tallman. “[Resistance] is a concern, yes, but it doesn’t negate our excitement about the future.”

(MORE: Inside America’s Drug Shortage)

Working in the doctors’ – and patients’ – favor is the fact that cancers aren’t monolithic entities composed of the same abnormal cell copied thousands of times over. Individual tumors may be composed of different types of aberrant cells, possessing a variety of mutations that are susceptible to different drugs. And this cast of cells can be ever-changing over the course of an individual patient’s battle with the disease.

While such heterogeneity and unpredictability could, on one hand, make tumors too daunting to tackle, they also represent an opportunity to employ an entirely new way of fighting tumors. Traditionally, if a tumor developed resistance to a chemotherapy agent, doctors would have abandoned it completely and moved on to another drug or another treatment strategy. But now they are able to biopsy tumors and perform more sophisticated genetic and molecular tests that help them to decide, for example, that the bulk of a tumor remains susceptible to a targeted therapy while only a small portion has become resistant. They can then either remove the resistant portion surgically or add another targeted therapy to tackle just that portion while keeping the patient on the original regimen that will still treat the remainder of his cancer. “That’s a new concept,” says Demetri. “That didn’t exist before targeted therapies.”

(MORE: The Screening Dilemma – Health Special: Cancer)

For patients, these types of creative strategies could mean gentler, more tolerable cancer treatments, and more years of living cancer-free.

Combinations of drugs may become the norm, much as they have become the standard for treating HIV infections. So far, says Dr. Scott Kopetz, associate professor of gastrointestinal oncology at MD Anderson Cancer Center, refined targeted therapy cocktails appear to work best for blood cell and immune cell cancers like chronic leukemias that tend to be more homogenous from the start, making them susceptible to the newer drugs. Solid tumors such as those in the breast, prostate and lung generally contain a wider variety of genetically different cells even at diagnosis, which makes them more challenging – although not impossible – to treat with targeted drugs. “Where there is a lot of genetic heterogeneity, such as in most solid tumors, there is more headwind we have to fight against, more opportunities for rapid resistance to develop,” says Kopetz.

That means that for the time being, chemotherapy may remain part of the cancer doctor’s arsenal – and even these agents are being revamped to cause fewer side effects. New ways of encasing the toxin in fat-based bubbles or linking it to nano-particles that deliver the drug just to the tumors while bouncing off of healthy cells are making regimens more tolerable.

Increasingly, though, chemotherapy may become the treatment of last resort, rather than the first wave as some basic truths about cancer are being knocked down and rewritten. For instance, it may not be as helpful to treat cancers by where they originate – in the breast or prostate or lung – but rather by the processes that fuel them. That’s why a targeted drug developed to treat melanomas is now used to suppress lung cancers, and why genetic and molecular analyses of tumors are becoming more critical to match the right medications to the right cancers.

“Many, many fundamental concepts in cancer are being challenged now based on new information,” says Tallman. “Of course that is leading to major shifts, paradigm shifts in treatment approaches, and ultimately, I think, better care patients and better outcomes.”

Ο πληθυσμός της Γης θα ξεπεράσει τα 11 δισεκατομμύρια

Θα τετραπλασιαστούν οι γεννήσεις στην αφρικανική ήπειρο

Ο παγκόσμιος πληθυσμός θα αγγίξει τα 11 δισεκατομμύρια μέχρι το τέλος του αιώνα που διανύουμε, λόγω του αυξανόμενου ρυθμού γεννήσεων στην Αφρική, αναφέρει νέα έρευνα.

Η τελευταία πρόβλεψη κάνει λόγο για περίπου 800 εκατομμύρια (ποσοστό 8%) παραπάνω συγκριτικά με την προηγούμενη πρόβλεψη των Ηνωμένων Εθνών το 2011 που ανέφερε ότι ο παγκόσμιος πληθυσμός θα έφτανε τα 10,1 δισεκατομμύρια ανθρώπους.

Οι ερευνητές ανέμεναν οι γεννήσεις στη φτωχότερη ήπειρο του κόσμου, όπου μια γυναίκα γεννά κατά μέσο όρο 5,2 παιδιά κατά τη διάρκεια της ζωής της, θα έπεφταν πιο γρήγορα απ’ ό,τι τελικά συμβαίνει.

Ο πληθυσμός της αφρικανικής ηπείρου τώρα φτάνει τα 1,1 δισεκατομμύρια και εκτιμάται να ξεπεράσει τα 4,2 δισεκατομμύρια, σχεδόν να τετραπλασιαστεί, μέχρι το 2100.

«Η μείωση της γονιμότητας στην Αφρική έχει επιβραδυνθεί ή και σταματήσει σε μεγαλύτερο βαθμό απ΄ ό,τι είχε προβλεφθεί, με αποτέλεσμα ο πληθυσμός της Αφρικής να αυξηθεί» σύμφωνα με τον καθηγητή του πανεπιστημίου της Washington, Adrian Raftery.

Μελέτη που έγινε την περασμένη χρονιά εκτιμούσε ότι ένα στα τρία παιδιά που θα γεννιούνται το 2050 θα είναι στην Αφρική, γράφει η βρετανική Daily Mail.

Σε άλλες περιοχές του πλανήτη αναμένονται λιγότερο σημαντικές αλλαγές στον πληθυσμό. Η Ευρώπη ενδέχεται να γνωρίσει μικρή μείωση του πληθυσμού της, λόγω του μικρού αριθμού των γεννήσεων, ενώ άλλα έθνη παγκοσμίως μπορεί να δουν μικρές αυξήσεις λόγω της επιμήκυνσης του προσδόκιμου ζωής, αναφέρει ο καθηγητής.

Ο παγκόσμιος πληθυσμός είχε φτάσει τα 7 δισεκατομμύρια το 2011, έχοντας ξεπεράσει τα έξι δισεκατομμύρια το 1999, καταλήγει το δημοσίευμα.

Ark Encounter’, Noah’s Ark Theme Park, Hopes To Show Biblical Flood Was ‘Plausible’

The Biblical account of Noah and his Ark poses a lot of questions, even for believers like the creators of the controversial Creation Museum in Kentucky.

What is “gopher wood”? How did Noah fit all those animals on the boat? And how did he stand the smell?

In an office park in Hebron, Kentucky, the designers of the proposed “Ark Encounter” theme park are trying to answer questions like these in order to build faith in the Bible’s literal accuracy. The project has run into delays because of lack of financing, which could cost it millions in potential tax breaks. Despite the uncertainty, a recent Reuters preview of the project showed that plans for the ark are continuing.

“We’re basically presenting what the Bible has to say and showing how plausible it was,” said Patrick Marsh, design director for the park, which will feature a 500-foot-long wooden ark and other Old Testament attractions, including a Tower of Babel and a “Ten Plagues” ride. “This was a real piece of history – not just a story, not just a legend.”

The project is currently in the design phase. Not enough private donations have come in to start construction, and building permits will not be ready until November, according to Ark Encounter co-founder and Senior Vice President Michael Zovath.

The project has $12.3 million in hand and $12.7 million more in committed donations; it needs $23 million more to start building the ark alone. Zovath does not know when that will happen.

Like Noah before the Flood, the builders are in a bit of a time crunch, since Kentucky tourism tax incentives for the project are set to expire in May 2014.

The longer it takes to start building the $150 million park, originally planned to open in spring 2014, the less the project stands to gain from the rebates, which allow it to receive up to 25 percent of project costs over 10 years from sales taxes generated by the business.

Zovath said the project may refile for the incentives, which critics argue are a violation of the constitutional divide between church and state. If the rebates applied to the full project cost, they could amount to $37.5 million.

SPECULATING ON THE ARK SPECS

Ark Encounter is a project of Answers in Genesis, the ministry founded by creationism proponent Ken Ham. The ministry built the Creation Museum in nearby Petersburg.

The museum, which has been harshly criticized by educators and scientists, argues that the earth is around 6,000 years old and was created by God in six 24-hour days with dinosaurs existing at the same time as humans. It rejects the theory of evolution and explains phenomena like the Grand Canyon as a consequence of the Flood.

Attendance at the Creation Museum has declined since it attracted 400,000 visitors in the first year after its 2007 opening, said Zovath. He attributes this to the poor economy and believes some visitors may be delaying their visits until the ark exhibit opens.

The Biblical account of the ark does not provide much detail on how it was made, so the designers have had to speculate.

The Bible calls for gopher wood, for instance, although it is unclear if this is a now-extinct type of wood or if the term refers to the way the wood was cut, said Marsh, who has done work for Universal Studios. Ark Encounter will go with a mix of woods.

Another big question is how Noah got mating pairs of all the animals of the earth, including dinosaurs, onto a boat half the length of a cruise ship.

Scientists have cataloged 1.3 million species of animals, but Ark Encounter protagonists figure Noah could have brought on just 1,000 to 2,000 pairs to represent every animal “kind,” as the Bible puts it.

“If you start with a wolf, you can basically generate all of these dog-like kinds,” said Marsh. As for large animals like dinosaurs, Marsh said Noah could have brought them on as eggs or juveniles, to save room.

Though the park is meant to teach that the Noah story is true, it is also for profit, and Marsh takes inspiration from secular theme parks. In the exhibit depicting the wicked pre-Flood society that God wanted to destroy, for example, Marsh plans a pagan temple with pagan ceremonies done in a “Disneyesque” way.

“You want everyone to have fun and buy souvenirs and have a good time, but you also want to tell everybody how terrible everything (was),” Marsh said.

He also plans exhibits within the three-level ark on how animal waste could have been taken away by mechanical devices and how fresh air could have been brought in.

CONSTITUTIONAL VIOLATION?

Explanations about the origins of the earth from Answers in Genesis are contrary to scientific consensus, which says that the planet formed about 4.5 billion years ago.

The Creation Museum was condemned by the National Center for Science Education, which said that students who accept material presented at the museum as valid are “unlikely to succeed in science courses at the college level.”

Many Biblical scholars interpret the Creation and Flood stories as poetic myths and not history.

About one out of three Americans accepts the Bible literally, a percentage that has declined over time, according to a 2011 Gallup poll. Nevertheless, creationism has in recent years re-entered public debate over how to teach science in schools.

Marsh said that while you can be a Christian without believing in creationism, you are on a “slippery slope.”

“So many people have gotten hooked with the concept of evolution that it really makes their faith very delicate,” he said.

Barry Lynn, a United Church of Christ minister who heads Americans United for Separation of Church and State, said the planned park promotes “junk science.”

“You don’t pay for the ministry of people out of the taxpayer’s collected dollars,” said Lynn, who said his group will consider a lawsuit if the tax breaks for the ark ever kick in.

Zovath argues that the tax breaks do not violate the Constitution, since the state is not giving the park money up-front, but is only returning some of the tourism money the park will bring to the state.

“If somebody wants to come into Kentucky and build a Harry Potter park and teach all the fun things about witchcraft, nobody would say a word about it – they’d just think it was so cool,” Zovath said. “But if we want to come in … and build a Biblical theme park, everybody goes crazy.”

(Editing by Arlene Getz and Prudence Crowther)

Eurovision 2013 – All 39 Songs

Eurovision Song Contest 2013:

SWEDEN – Robin Stjernberg – You
NORWAY – Margaret Berger – I Feed You My Love
UKRAINE – Zlata Ognevich – Gravity
ITALY – Marco Mengoni- L’essenziale
ISRAEL – Moran Mazor – Rak bishvilo (Only For Him)
SERBIA – Moje 3 – Ljubav je svuda
DENMARK – Emmelie de Forest – Only Teardrops
GERMANY – Cascada – Glorious
GREECE – Koza Mostra & Agathonas Iakovidis – Alcohol Is Free

CROATIA – Klapa sa mora – Mižerja
AUSTRIA – Natalia Kelly – Shine
UNITED KINGDOM – Bonnie Tyler – Believe in Me
SWITZERLAND – Takasa – You and Me
MONTENEGRO – Whoo see Feat. Nina Zizic – Igranka
AZERBAIJAN – Farid Mammadov – Hold Me
BELGIUM – Roberto Bellarosa – Love Kills
RUSSIA – Dina Garipova – What If
BULAGARIA – Elitsa Todorova & Stoyan Yankoulov – Samo shampioni (Само шампиони)
FYR MACEDONIA – Esma Redzepova Vlatko Lozano – Pred da se razdeni (Пред да се раздени)
SAN MARINO – Valentina Monetta – Crisalide
FINLAND – Krista Siegfrids – Marry Me
SPAIN – ESDM – Contigo hasta el final
MOLDOVA – Aliona Moon – O mie (A thousand)
BELARUS – Alyona Lanskaya – Solayoh
SLOVENIA – Hannah – Straight Into Love
GEORGIA – Nodi Tatishvili & Sophie Gelovani – Waterfall
THE NETHERLANDS – Anouk – Birds
ARMENIA – Dorians – Lonely Planet
FRANCE – Amandine Bourgeois – L’enfer et moi
CYPRUS – Despina Olympiou An Me Thimase (Αν Με Θυμάσαι)

HUNGARY – ByeAlex – Kedvesem
ALBANIA – Adrian Lulgjuraj & Bledar Sejko – Identitet
LATVIA – PeR – Here we go
IRELAND – Ryan Dolan – Only Love Survives
LITHUANIA – Andrius Pojavis – Something
MALTA – Gianluca Bezzina – Tomorrow
ICELAND – Eyþór Ingi Gunnlaugsson – Ég á líf
ESTTONIA – Birgit Õigemeel – Et uus saaks alguse
ROMANIA – Cezar – It’s My Life

MAY 6: THE FIRST SET OF REHEARSALS BEGIN FEATURED

Source: oikotimes

Behind closed doors and available only through the monitors at the Euroclub, the 58th Eurovision Song Contest rehearsals kick off today.

First semifinal’s countries are taking the stage for the first technical rehearsal. Besides that we will keep you posted on further activities and backstage stories.

10:00-10:30 AUSTRIA (Natália Kelly)
10:40-11:10 ESTONIA (Birgit Õigemeel)
11:20-11:50 SLOVENIA (Hannah)
12:00-12:30 CROATIA (Klapa s Mora)
13:30-14:00 DENMARK (Emmelie de Forest)
14:10-14:40 RUSSIA (Dina Garipova)
14:50-15:20 UKRAINE (Zlata Ognevich)
15:30-16:00 NETHERLANDS (Anouk)